![]() ![]() 2 This theory was the accepted concept until Ahlquist 2 demonstrated that there were 2 subtypes of receptors in the class, which he termed and (Table 1). Interestingly, the pharmacological actions of specific alpha2 agonists and antagonists are likely the result of modulating these central receptors rather than those in the peripheral nervous system. Alpha-2 adrenoceptors are activated by the catecholamines norepinephrine and epinephrine, and are members of the adrenoceptor family of the 7-transmembrane superfamily of receptors. In early scientific theory of adrenergic mechanisms, it was believed that adrenergic receptors were classified into 2 groups: those whose actions resulted in either excitation or inhibition of effector cells. The central actions of alpha2 receptors are still being elucidated.
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